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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SAMHD1
All Species:
36.36
Human Site:
Y315
Identified Species:
66.67
UniProt:
Q9Y3Z3
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y3Z3
NP_056289.2
626
72201
Y315
I
D
V
D
K
W
D
Y
F
A
R
D
C
H
H
Chimpanzee
Pan troglodytes
XP_514624
382
43769
L100
S
L
G
E
R
K
K
L
L
S
Y
I
Q
R
L
Rhesus Macaque
Macaca mulatta
XP_001097562
728
83194
Y417
I
D
V
D
K
W
D
Y
F
A
R
D
C
H
H
Dog
Lupus familis
XP_542986
665
76981
Y353
I
D
V
D
K
W
D
Y
F
A
R
D
C
H
H
Cat
Felis silvestris
Mouse
Mus musculus
Q60710
627
72632
Y316
I
D
V
D
K
W
D
Y
F
A
R
D
C
H
H
Rat
Rattus norvegicus
XP_230789
677
77635
Y371
I
D
V
D
K
W
D
Y
F
A
R
D
C
H
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJL9
614
70202
Y306
I
D
V
D
K
W
D
Y
F
A
R
D
C
H
H
Frog
Xenopus laevis
Q6INN8
632
72730
Y320
I
D
V
D
K
W
D
Y
F
A
R
D
C
H
H
Zebra Danio
Brachydanio rerio
Q502K2
622
71649
Y295
I
D
V
D
K
W
D
Y
F
A
R
D
C
Y
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09374
587
66474
E281
T
F
S
E
S
T
L
E
R
L
F
N
H
V
R
Sea Urchin
Strong. purpuratus
XP_784786
594
68895
Y289
I
D
V
D
K
W
D
Y
F
A
R
D
C
Y
N
Poplar Tree
Populus trichocarpa
XP_002312899
477
54770
K195
P
K
N
D
A
G
E
K
R
F
L
Y
D
I
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_568580
473
54655
E191
S
Q
L
K
G
N
A
E
K
R
F
L
Y
D
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.9
79.5
73.5
N.A.
73.3
65.8
N.A.
N.A.
60
61.8
60.8
N.A.
N.A.
N.A.
22.5
46.8
Protein Similarity:
100
60.2
82.4
83.6
N.A.
83.2
76.2
N.A.
N.A.
74.9
75.3
74.1
N.A.
N.A.
N.A.
40.8
64.2
P-Site Identity:
100
0
100
100
N.A.
100
100
N.A.
N.A.
100
100
93.3
N.A.
N.A.
N.A.
0
86.6
P-Site Similarity:
100
20
100
100
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
N.A.
N.A.
13.3
100
Percent
Protein Identity:
28.2
N.A.
N.A.
30.5
N.A.
N.A.
Protein Similarity:
45
N.A.
N.A.
47.2
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
8
0
0
70
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
70
0
0
% C
% Asp:
0
70
0
77
0
0
70
0
0
0
0
70
8
8
0
% D
% Glu:
0
0
0
16
0
0
8
16
0
0
0
0
0
0
0
% E
% Phe:
0
8
0
0
0
0
0
0
70
8
16
0
0
0
0
% F
% Gly:
0
0
8
0
8
8
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
8
54
62
% H
% Ile:
70
0
0
0
0
0
0
0
0
0
0
8
0
8
8
% I
% Lys:
0
8
0
8
70
8
8
8
8
0
0
0
0
0
0
% K
% Leu:
0
8
8
0
0
0
8
8
8
8
8
8
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
8
0
0
0
0
0
8
0
0
8
% N
% Pro:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
0
% Q
% Arg:
0
0
0
0
8
0
0
0
16
8
70
0
0
8
8
% R
% Ser:
16
0
8
0
8
0
0
0
0
8
0
0
0
0
0
% S
% Thr:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
70
0
0
0
0
0
0
0
0
0
0
8
8
% V
% Trp:
0
0
0
0
0
70
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
70
0
0
8
8
8
16
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _